مقالات  فرامرز كوشش  


  Hepatitis E Virus Seroprevalence Among Blood Donors in Bushehr, South of Iran Hepat mon 2015 November; 15(11): e29219 ISI Behrouz Naeimi,1,2 Farnaz Mazloom Kalimani,3 Ali Akbar Pourfatolah,4 Masoud Azimzadeh,3 Alireza Mankhian,5 Samad Akbarzadeh,6 Gholamreza Hajiani,5 Faramarz Kooshesh,7 and Gholamreza Khamisipour2,8,* هشتم از نهم
Background: Although so far several studies have determined the hepatitis E virus (HEV) prevalence in some parts of Iran, no data exists regarding the HEV seroprevalence in Bushehr province as the southernmost point in Iran yet. Objectives: The aim of this study was to evaluate the seroprevalence of anti-HEV IgG among the blood donors in Bushehr. Patients and Methods: A total of 628 blood donor samples were collected from September to October 2013, after obtaining informed written consents, and analyzed for the presence of anti-HEV IgG using commercial HEV enzyme-linked immunosorbent assay (ELISA) kit. All the samples were tested by two ELISA kits and evaluated for liver function test. Results: Overall, 105 (16.7%) blood samples were positive for HEV-specific-IgG antibodies, while 523 (83.8%) were negative. The presence of anti-HEV IgG was not associated with gender; however, it was correlated with age. It was indicated that the anti-HEV prevalence increases by age and there was a significant difference between the age groups regarding HEV seropositivity. Conclusions: High HEV seroprevalence (16.7%) was observed among the blood donors in Bushehr province. It appears that exposure to HEV increases with age; although, more people should be examined. Keywords: Hepatitis E Virus, Seroepidemiological Studies, Enzyme-Linked Immunosorbent Assay, Blood Donors, Iran
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doi: 10.5812/hepatmon.29219
  Arrhythmogenic Risk Assessment Following Four-Week Pretreatment With Nicotine and Black Tea in Rat Research in Cardiovascular Medicine 2015, Volume 4, Issue 3, Aug pubmed Siyavash Joukar 1,2,3,*; Vahid Sheibani 2,3; Faramarz Koushesh 4; Elham Ghasemipoor Afshar 1,3; Soodabe Ghorbani Shahrbabaki 1 سوم از پنجم
Background: There is the controversy concerning the main component of tobacco, which is responsible for its arrhythmogenesis. In addition, there is the lack of adequate information about the influence of combination of black tea and nicotine on heart rhythm. Objectives: This study aimed to examine whether pretreatment with black tea and nicotine could modulate the susceptibility to lethal ventricular arrhythmias. Materials and Methods: Animals were randomized to control, black tea, nicotine, and black tea plus nicotine groups. Test groups were treated with black tea brewed (orally) and nicotine (2 mg/kg, subcutaneous), alone and in combination for four weeks. On day 29, aconitine was infused intravenously for induction of cardiac arrhythmia. Results: In comparison with the control group, each of tea and nicotine significantly decreased the duration of the ventricular tachycardia (VT) plus ventricular fibrillation (VF) and the score of arrhythmia severity (P < 0.05 and P < 0.01, respectively,). The latency for the first VT event was significantly longer in the all test groups, but VF latency was significant only in tea and nicotine groups compared with control group (P < 0.05 and P < 0.01, respectively).Threshold dose of aconitine for inducing VT and VF increased in all test groups, but only VT showed a significant difference in comparison to the control group (P < 0.001). Conclusions: The findings suggest that sub-chronic consumption of nicotine or black tea alone with appropriate doses could potentially be antiarrhythmic and its combination regimen does not increase the risk of fatal ventricular arrhythmias during four-week consumption period in rats. Keywords: Ventricular Arrhythmia, Black Tea, Nicotine
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DOI: 10.5812/cardiovascmed.27088v2
  Blood ordering and utilization in hospitals of Bushehr province کنگره بین المللی خون، بیماری ها و ... اردیبهشت ماه 1394 فرامرز کوشش ـ غلامرضا خمیسی پور ـ رحیم طهماسبی اول از سوم
Background: Cross over ordering of blood much in excess of actual or anticipated needs led to rising costs and transfusion associated morbidity. In order to reveal blood utilization, we evaluated blood ordering and transfusion practices in 437 cases in general surgery, obstetrics & gynecology, orthopedics, neurology and urology wards of different hospitals in Bushehr province using cross-match to transfusion ratio(C/T ratio)and transfusion index (TI).The maximum(8.9) and minimum (1.2)ratio for C/T index were in obstetrics and gynecology and orthopedics ward, respectively .The maximum(1.85)and minimum (0.70)TI index were in orthopedics and obstetrics &gynecology wards ,respectively. TI indices for general surgery and urology wards were 0.59 and 0.70 ,respectively. Therefore, blood ordering and transfusion practices in some wards of Bushehr hospitals , especially obstetrics and gynecology ward , should be reevaluated. Key words: Blood Banking , Hospital , Blood Transfusion , Surgery.
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  Determination of Hepatitis E Virus seroprevalence among blood donors in Bushehr, Iran کنگره بین المللی خون، بیماری ها و ... اردیبهشت ماه 1394 نه از یازده
Background: Hepatitis E virus (HEV) infection is commonly an acute hepatitis which caused by a non-enveloped, single stranded RNA virus belongs to genus Hepevirus, family Hepeviridae. This virus remains infectious in sewage, therefore can be transmitted by fecal-oral route especially fecal contaminated water in developing countries. Blood transfusion and zoonotic HEV infection have a role in spread of the virus in developed countries where sporadic cases of HEV infection have been reported. There is an evidence demonstrating that persons who receive blood from HEV infected blood donors, experience acute hepatitis after blood transfusion. This virus has been infected one-third of the world's population. The clinical symptoms of HEV infection are acute, self-limited hepatitis in healthy individualsAlthough so far several studies have determined HEV prevalence in some parts of Iran but still no data exists regarding HEV seroprevalence in Bushehr province. The aim of this study was to evaluate the seroprevalence of anti-HEV IgG among blood donors in Bushehr.
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